1. DNA Binding Studies of Anti-Cancer Agents
Collaborator: Ahmed Kamal ,IICT, Hyderabad
2. Genomics of Wild Silkmoths
Collaborator: Dr.J.Nagaraju, CDFD
3. Moldelling studies of the prokaryotic (Mtb and Ecoli) RNA polymerase elongation complex (Cheeran et al, 2005)
Collaborator: Dr.Ranjan Sen, CDFD
4. BioSuite-A comprehensive bioinformatics software package (NMITLI-BioSuite Team, 2007)
5. Structural analysis of Rho mutants through molecular dynamics simulations
Collaborator: Dr. Ranjan Sen, Laboratory of Transcription Biology, CDFD
Transcription termination is one of the most essential processes required for accurate gene expression involving identification of a specific signal sequence in the transcribing gene. In prokaryotes Rho-factor is one of the two transcription termination mechanisms. Transcription biology group at CDFD has identified few mutations (Chalissery et al, communicated), which have been found to show defective transcription termination both in vivo and in vitro. Using molecular dynamics as a tool we have been investigating the time evolution and time averaged structural properties of rho mutants.
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Publications
Genomics of Wild Silkmoths
A.Kamal, N. Laxman, G. Ramesh, P. Ramulu, O. Srinivas, K. Neelima, A. K. Kondapi, V. B. Sreenu and H.A.Nagarajaram 2002 Design, synthesis, and evaluation of new non-cross linking pyrrolobenzodiazepine dimers with efficient DNA-binding ability and potent antitumour activity J. Med. Chem 45 4679-4688.
Ahmed Kamal, G. Ramesh, O. Srinivas, P. Ramulu, N. Laxman,Tasneem Rehana, M.Deepak, M.S. Acharya and H. A. Nagarajaram. Design, Synthesis, and Evaluation of Mixed Imine-Amine Pyrrolobenzodiazepine Dimers with Efficient DNA-Binding Affinity and Potent Cytotoxicity. Bio-organic & Medicinal Chemistry (2004)12, 5427-5436.
Anoop Cheeran, Rajan Babu Suganthan, G. Swapna, Irfan Bandey, M. Sridhar Acharya, H. A. Nagarajaram and Ranjan Sen. Escherichia coli RNA Polymerase Mutations Located Near the Upstream Edge of an RNA:DNA Hybrid and the Beginning of the RNA-exit Channel are Defective for Transcription Antitermination by the N Protein from Lambdoid Phage H-19B. J. Mol. Biol. (2005) 352, 28-43
The NMITLI-BioSuite Team. (M.S. Acharya, Part of the team). BioSuite: A comprehensive bioinformatics software package (A unique industry–academia collaboration). Curr. Sci. (2007) 92 (1), 29-38 |
