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Dr. Murali Bashyam
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Molecular Oncology Group
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Home » Molecular Oncology » Research
Molecular Oncology
Clinical and molecular genetic analysis of squamous cell carcinoma of the tongue, funded by Indian Council for Medical Research (ICMR) and Council for scientific and industrial research (CSIR).

Tongue cancer accounts for about 6-8% of all cancers in India and about a fourth of all Head and Neck cancers. Tongue cancer is unique in head and neck cancer because of its relatively higher incidence in the younger age group as well as in nonsmokers. It is also the most aggressive subtype of Head and Neck cancers due to a propensity for rapdid metastatic spread. We have performed the first comprehensive molecular and clinico-pathological analysis of squamous cell carcinoma of the mobile tongue occurring in India. Results reveal interesting features with respect to status of EGFR, P53, microsatellite instability and loss of heterozygosity of specific chromosomal loci. We have initiated genome wide DNA copy number and transcript profile analysis to study specific genetic alterations occurring in tumors harboring a wild type P53.

Raju SR Adduri: SRF
Pratyusha Bala:JRF
K Rajendra: Project assistant
Contact Information
Email: bashyam<at>cdfd.org.in

Phone: +91-40-24749383
Fax: +91-40-24749448
Last updated on : Thursday 26thSeptember, 2013.

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