This enzyme is known to be overexpressed in isoniazid resistant strains of M. tuberculosis, and has been shown to be important for its virulence. It therefore acts as a good drug target. We have characterized the enzyme in its biochemical details. A high throughput screen for finding inhibitors has also been set up. Attempts to crystallize the enzyme are under progress, and promising crystals have been observed.
Recent publications:
Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase
AhpC points to the importance of ionic interactions in oligomerization
and activity.
R. Chauhan and S. C. Mande
Biochem J. (2001) 354, 209- 215.
Mycobacterium tuberculosis Alkylhydroperoxidase C belongs to a novel
3-Cysteine peroxiredoxin family.
R. Chauhan and S. C. Mande
Biochem J. (2002) 367, 255- 261.
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