SEMINAR



"Integrin Based Strategies to Cure HIV/AIDS"




By
Dr Siddappa Byrareddy
Department of Pharmacology and Experimental Neuroscience
Nebraska Center for Substance Abuse Research
Durham Research Center
Nebraska Medical Center, Omaha



On
24th April, 2018
12:00 noon


At
Seminar Hall,
3rd floor
Uppal Campus

ABSTRACT :

Abstract: During acute infection, HIV/SIV targets gut CD4+ T cells and macrophages that express high numbers of CCR5-expressing activated CD4+ T cells. The integrin a4+7 is found at high levels on the surface of some CD4+ T cells and is involved in gut- cell trafficking. Increased frequency of a4ß7hi-expressing CD4+ T cells within the gastrointestinal associated lymphoid tissues (GALT) during infection appears to correlate with increased viral loads and enhanced disease progression. Our recent studies demonstrated that administration of anti-a4ß7mAb to ART-treated SIV-infected RMs resulted in significant suppression of plasma/GALT viral loads even after ART treatment interruption. Based on these findings two clinical trials were already initiated. Recent findings on the role of a4ß7 in sustaining virological control will be presented. prophylactic therapeutics for disease prevention.