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Dr.Sangita Mukhopadhyay
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Home » Molecular Cell Biology » Publications
Molecular Cell Biology
  1. Vishwanath Jha, Ravi Pal, Dhiraj Kumar, and Sangita Mukhopadhyay (2020). ESAT-6 protein of Mycobacterium tuberculosis increases holotransferrin mediated iron uptake in macrophages by downregulating surface hemochromatosis protein HFE. Journal of Immunology (In Press)

  2. Komal Dolasia , Faiza Nazar and Sangita Mukhopadhya (2020). Mycobacterium tuberculosis PPE18 protein inhibits MHC class II antigen presentation and B cell response in mice European Journal of Immunology (In Press)

  3. Jha V, Rao RN, Janardhan S, Raman R, Sastry GN, Sharma V, Rao JS, Kumar D and Mukhopadhyay S (2019). Uncovering structural and molecular dynamics of ESAT-6:β2M interaction: Asp53 of human β2-Microglobulin is critical for the ESAT-6:β2M complexation. Journal of Immunology(In Press)

  4. Srivastava S, Battu MB, Khan MZ, Nandicoori VK, Mukhopadhyay S. Mycobacterium tuberculosis PPE2 Protein Interacts with p67(phox) and Inhibits Reactive Oxygen Species Production. J Immunol. 2019 Aug 2. pii: ji1801143. doi: 10.4049/jimmunol.1801143

  5. Pal R, Nazar F and Mukhopadhyay S* . The PE and PPE family proteins of Mycobacterium tuberculosis: What they are upto? (2019) A chapter in the book titled "Mycobacterium tuberculosis:Molecular & Functional Epidemiology, Virulence, and Pathogenesis" published by Springer.

  6. Udgata A, Dolasia K, Ghosh S, Mukhopadhyay S Dribbling through the host defence: targeting the TLRs by pathogens. Crit Rev Microbiol. 2019 May;45(3):354-368.

  7. Pradhan G, Raj Abraham P, Shrivastava R, Mukhopadhyay S . Calcium Signaling Commands Phagosome Maturation Process. Int Rev Immunol 2019;38(2):57-69.

  8. Abraham PR, Devalraju KP, Jha V, Valluri VL and Mukhopadhyay S (2018). PPE17 (Rv1168c) protein of Mycobacterium tuberculosis detects individuals with latent TB infection. PLoS One (In press).

  9. Qureshi R, Rameshwaram NR, Battu MB and Mukhopadhyay S (2018). PPE65 of M. tuberculosis regulate pro-inflammatory signalling through LRR domains of Toll like receptor-2. Biochem Biophys Res Commun. 2018 Nov 21. pii: S0006-291X(18)32518-X.

  10. N. R. Rameshwaram, P.Singh, S. Ghosh and S. Mukhopadhyay (2018). Lipids and lipases in the physiology and pathogenicity of Mycobacterium tuberculosis and other intracellular bacteria. Future Microbiology Microbiology – In Press.

  11. P. Singh, N. R. Rameshwaram, S. Ghosh and S. Mukhopadhyay (2018). Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis. Future Microbiology 13: 689-710.

  12. G. Pradhan, R. Shrivastva, and S. Mukhopadhyay (2018). Mycobacterial PknG Targets the Rab7l1 Signaling Pathway To Inhibit Phagosome–Lysosome Fusion. Journal of Immunology 201(5):1421-1433.

  13. A. Ahmed, K. Dolasia and S. Mukhopadhyay (2018). Mycobacterium tuberculosis PPE18 Protein Reduces Inflammation and Increases Survival in Animal Model of Sepsis. Journal of Immunology. April 18, 2018, doi:10.4049/jimmunol.1602065.

  14. K. Dolasia, M. K. Bisht, G. Pradhan, A. Udgata & S. Mukhopadhyay (2017). TLRs/NLRs: Shaping the landscape of host immunity. International Reviews of Immunology. doi:10.1080/08830185.2017. 1397656.

  15. P.R. Abraham, N. Pathak, G. Pradhan , G. Sumanlatha and S. Mukhopadhyay (2017). The N-terminal domain of Mycobacterium tuberculosis PPE17 (Rv1168c) protein plays a dominant role in inducing antibody responses in active TB patients. PLoS One 26: e0179965.

  16. S. Mukhopadhyay and S. Ghosh (2017). Mycobacterium tuberculosis: what is the role of PPE2 during infection? Future Microbiology 12: 457-460. doi: 10.2217 (Invited Editorial Article).

  17. K.H. Bhat , S. Srivastava , S.K. Kotturu , S. Ghosh and S. Mukhopadhyay (2017). The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production. Scientific Reports7:39706.

  18. R. N. Rao, R. Shrivastava, G. Pradhan, P. Singh and S. Mukhopadhyay (2017). Phagosome lysosome Fusion Hijack - An Art of Intracellular Pathogens. Proceedings of the Indian Academy of Science doi: 10.16943/ptinsa/2017/48971

  19. A. Udgata, R. Qureshi and S. Mukhopadhyay (2016). Transduction of functionally contrasting signals by two mycobacterial PPE proteins downstream of TLR2 receptors. Journal of Immunology 197(5):1776-1787.

  20. Parul Singh, Rameshwaram Nagender Rao, Jala Ram Chandra Reddy, RBN Prasad, Sandeep Kumar Kotturu, Sudip Ghosh & Sangita Mukhopadhyay (2016). PE11, a PE/PPE family proteinof Mycobacterium tuberculosis is involved in cell wall remodeling and virulence. Scientific Reports, 6:21624. doi: 10.1038/srep21624.

  21. P. R. Abraham, A. Udgata, G. S. Latha, and S. Mukhopadhyay (2016). The Mycobacterium tuberculosis PPE protein Rv1168c induces stronger B cell response than Rv0256c in active TB patients. Infection Genetics and Evolution, 40:339-345

  22. A. Ahmed, A. Das and S. Mukhopadhyay (2015). Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti-tuberculosis vaccine and drug design. IUBMB Life 67:414-427.

  23. K. Hussain Bhat and S. Mukhopadhyay (2015). Macrophage takeover and the host-bacilli interplay during tuberculosis. Future Microbiol. 10: 853-872.

  24. G. Sreejit, A. Ahmed, N. Parveen, V. Jha, V. L.Valluri, S. Ghosh and S. Mukhopadhyay (2014). The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (.2M) affecting antigen presentation function of macrophage. PLoS Pathogens 10:e1004446.

  25. P. R. Abraham, G. S. Latha, V. L. Valluri and S. Mukhopadhyay (2014). Mycobacterium tuberculosis PPE protein Rv0256c induces strong B cell response in tuberculosis patients. Infection Genetics and Evolution 22:244-249.

  26. K. H. Bhat, A. Das, A. Srikantam and S. Mukhopadhyay (2013) PPE2 protein of Mycobacterium tuberculosis inhibits production of nitric oxide in activated macrophages. Annals of the New York Academy of Sciences 1283:97-101.

  27. N. Parveen, R. Varman, S. Nair, G. Das, S Ghosh and S. Mukhopadhyay (2013). Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages. Journal of Biological Chemistry 288:24956-24971.

  28. K. H. Bhat, A. Ahmed, S. Kumar, P. Sharma and S. Mukhopadhyay (2012). Role of PPE18 protein in intracellular survival and pathogenicity of Mycobacterium tuberculosis in mice. PLoS ONE 7:e52601.

  29. Y. Akhter, M. T. Ehebauer, S. Mukhopadhyay , and S. E. Hasnain (2012). The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: perhaps more? Biochimie 94:110-116.

  30. K. H. Bhat, C. K. Chaytanya, N. Parveen, R. Varman, S. Ghosh and S. Mukhopadhyay (2012). The PPE protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 LTR promoter. Journal of Biological Chemistry 287:16930-16946.

  31. S. Mukhopadhyay, S. Nair and S. Ghosh (2011). Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiology Reviews 36:463-485.

  32. S. Mukhopadhyay and K. N. Balaji (2011). The PE and PPE proteins of Mycobacterium tuberculosis. Tuberculosis 91:441-447.

  33. A. Das and S. Mukhopadhyay (2011). The evil axis of obesity, inflammation and type-2 diabetes. Endocrine, Metabolic & Immune Disorders - Drug Targets 11:23-31.

  34. S. Nair, A. D. Pandey and S. Mukhopadhyay (2011). The PPE18 protein of Mycobacterium tuberculosis inhibits NF-kB/rel-mediated proinflammatory cytokine production by upregulating and phosphorylating SOCS3 protein. Journal of Immunology 186:5413-5424.

  35. K. Alam, S. Ghousunnissa, S. Nair, V. L. Valluri, and S. Mukhopadhyay (2010). Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in antituberculosis immunotherapy. Journal of Immunology 184:2918-2929.

  36. S. Nair, P. A. Ramaswamy, S. Ghosh, D. C. Joshi, N. Pathak, I. Siddiqui, P. Sharma, S. E. Hasnain, S. C. Mande, and S. Mukhopadhyay (2009). The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. Journal of Immunology 183:6269-6281.

  37. N. Bashir, F. Kounsar, S. Mukhopadhyay, and S. E. Hasnain (2010). Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions. Immunology 130:34-45.

  38. M. A. Hussain, S. A. Naveed, L. A. Sechi, S. Ranjan, A. Alvi, I. Ahmed, A. Ranjan, S. Mukhopadhyay, and N. Ahmed (2008). Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritis. PLoS ONE 3:e1481.

  39. S. Tundup, N. Pathak, M. Ramanadham, S. Mukhopadhyay, K. J. Murthy, N. Z. Ehtesham, and S. E. Hasnain (2008). The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 3:e3586.

  40. N. Khan, K. Alam, S. Nair, V. L. Valluri, K.J. R. Murthy and S. Mukhopadhyay* (2008). Strong immune responses to the PPE protein Rv1168c are associated with active tuberculosis disease. Clinical and Vaccine Immunology 15:974-980.

  41. N. Khan, K. Alam, S. C. Mande, V. L. Valluri, S. E. Hasnain and S. Mukhopadhyay (2008). Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages. Cellular Microbiology 10:1711-1722.

  42. N. Khan, S. Ghousunnissa, S. M. Jegadeeswaran, D. Thiagarajan, S. E. Hasnain, and S. Mukhopadhyay* (2007). Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-kB-dependent pathway. International Immunology 19:477-486.

  43. S. Mukhopadhyay, S. Nair, and S. E. Hasnain (2007) Nitric oxide: Friendly rivalry in tuberculosis. Current Signal Transduction Therapy 2:121-128.

  44. C. S. Boddupalli, S. Ghosh, S. S. Rahim, S. Nair, N. Z. Ehtesham, S. E.. Hasnain and S. Mukhopadhyay (2007). Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel. Free Radical Biology and Medicine 42:686-697.

  45. N. Khan, S. S. Rahim, C. S. Boddupalli, S. Ghousunnissa, S. Padma, N. Pathak, D. Thiagarajan, S. E. Hasnain and S. Mukhopadhyay* (2006). Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Blood 107:1513-1520.

  46. S. S. Rahim, N. Khan, C. S. Boddupalli, S. E. Hasnain and S. Mukhopadhyay (2004). IL-10 mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114:313-321.

  47. N. Silswal, A. K. Singh, B. Aruna, S. Mukhupadhyay, S. Ghosh, and Z. Ehtesham (2005). Human resistin stimulates the pro-inammatory cytokines TNF-a and IL-12 in macrophages by NF-.B-dependent pathway. Biochemical and Biophysical Research 334:1092-1101.

  48. S. Ghosh, S. Rasheedi, S. S. Rahim, S. Banerjee, R. K. Choudhary, P. Chakhaiyar, N. Z. Ehtesham, S. Mukhopadhyay and S. E. Hasnain (2004). Method for enhancing solubility of the expressed recombinant proteins in Escherichia coli. Biotechniques 37:418-423.

  49. S. Mukhopadhyay, V. M. L. Srivastava, P. K. Murthy and S. E. Hasnain (2004). Poorer NF-kB signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. FEBS Letters 567:275-280.

  50. R. K. Choudhary, S. Mukhopadhyay, P. Chakhaiyar, N. Sharma, K. J. R. Murthy, V. M. Katoch and S. E. Hasnain (2003). PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B cell response. Infection Immunity 71:6338-6343.

  51. M. D. Bashyam and S. Mukhopadhyay (2003). Status of Tuberculosis in India-2003 (R. Nayak, M. S. Shaila and G. R. Rao eds.) and Trends in Malaria and Vaccine Research: The current Indian Scenario (D. Raghunath and R.Nayak eds.). Book Review, Infection, Genetics and Evolution 3:75-77.

  52. Ghosh, S., Singh, A. K., Aruna, B., S. Mukhopadhyay, and Ehtesham, N. Z. (2003). The genomic organization of mouse resistin reveals major difference from the human resistin. Gene 305:27-34.

  53. S. Bhatia, S. Mukhopadhyay, E. Jarman, G.Hall, A. George, S. Rath, J. R. Lamb, and V. Bal, (2002). Scavenger receptor-specific allergen delivery elicits IFN-g-dominated immunity and directs established Th2-dominated responses to a non-allergic phenotype. Journal of Allergy and Clinical Immunology 109:321-328.

  54. S. Mukhopadhyay, M. Mohanty, A. Mangla, A. George, V. Bal, S. Rath, and B. Ravindran (2002). Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial for microfilarial clearance than the cytokine balance of T cell responses. Journal of Immunology 168: 2914-2921.

  55. B. Ravindran, P. K. Sahoo, M. Mohanty, S. Mukhopadhyay and A. P. Dash (1999). Increased susceptibility of mice with XID mutation to Brugia malayi infection. Medical Science Research, 27:135-137.

  56. S. Mukhopadhyay, P. K. Sahoo, A. George, V. Bal, S. Rath and B. Ravindran (1999) Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice. Journal of Immunology 163:875-883.

  57. S. Mukhopadhyay, A. George, V. Bal, B. Ravindran and S. Rath (1999). Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of interleukin-12 induction. Journal of Immunology 163:1786-1792.

  58. S. Mukhopadhyay, A. P. Dash & B. Ravindran (1996) Setaria digitata in Mastomys coucha: An animal model for chemotherapeutic and immunobiological studies. Parasitology 113:323-330.

  59. S. Mukhopadhyay & B. Ravindran (1997) Antibodies to diethylcarbamazine potentiate the anti-filarial Immunology activity of the drug. Parasite 19:191-195.

List of Patents

  1. Mukhopadhyay S, Pal R and Battu MB. A novel therapeutic to treat inflammation and tissue injury. January 8, 2019 with application number 201941000876)

  2. S. Mukhopadhyay*, K. H. Bhat and N. Khan. A novel protein as potential candidate for development of anti-tuberculosis therapeutics.

    US Patent Application Number: 12/551,115;
    Invention ID: IN-000044-02-US-REG
    Patent No: US-8603739B2
    Date of grant: December 10, 2013

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Email: sangita<at>cdfd.org.in
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Last updated on: Friday, 20th November, 2020.

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