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Molecular Virology » Publications |
| Molecular Virology |
Publications of Dr.S.Mahalingam
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Subba Rao, M.R.K., Gita Kumari., D. Balasundaram., R. Sankaranarayanan and S. Mahalingam. (2006). A Novel Lysine-rich domain and GTP Binding Motifs Regulates the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3L. Journal of Molecular Biology. (In press).
Singhal,P. K., P. Rajendra Kumar., M. R. K. Subba Rao and S. Mahalingam (2006). Nuclear Export of Simian Immunodeficiency Virus Vpx Protein. Journal of Virology. (In press).
Du X, Subba Rao,MRK, Xue Qin Chen, Wei Wu, Mahalingam. S. and Balasundaram D. 2006. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. Mol. Biol. Cell 1; 460-474
Singhal PK, Rajendra Kumar P, Subba Rao MRK, Mahesh Kyasani and Mahalingam S. 2006 Simian Immunodeficiency Virus Vpx is imported in to the nucleus via importin alpha dependent and independent pathways. Journal of Virology 80: 526-536.
Varadarajan P*, Mahalingam S*, Gandotra,S, Dorairajoo DS, D Ysouza VM, Balasundarum D. (2005) The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr. Mol. Biol. Cell 16: 1823-1838.
Rajendra Kumar, P., Singhal, P.K, Subba Rao. M.R.K. and Mahalingam S. (2004) Phosphorylation by MAPK regulates simian immunodeficiency virus Vpx protein nuclear import and virus infectivity. J. Biol. Chem. 280: 8553-8563.
Tomkowicz, B., Singh, S.P., Lai, D., Singh, A., Mahalingam. S., Joseph, J., Srivastava, S. and Srinivasan, A. 2004. Mutational analysis reveals an Essential role for the LXXLL motif in the transfermation function of the human herpesvirus-8 Oncoprotein, Kaposin. DNA and Cell Biology 24: 10-20.
Rajendra Kumar, P., Singhal, P.K, Vinod, S.S and Mahalingam S. (2003) A non-canonical transferable signal mediates nuclear import of simian immunodeficiency virus Vpx protein. J Mol Biol. 331: 1141-56. 21.
Majumder, B., Gray, B., McBurney, S., Schaefer, T.M., Dentchev, T., Mahalingam, S., Reinhart, T.A and Ayyavoo, V. (2003) Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine. Immunol Lett. 89: 207-14.
Vanitharani R., Mahalingam S., Reddy. P. J., Singh. S.P., Srinivasan.A., Weiner. D. B. and V. Ayyavoo. 2001 HIV-1 Vpr Transactivates LTR-directed expression through Sequences present within -278 to -176 and increases virus replication In Vitro. Virology. 289: 334-342.
Mahalingam S, Van Tine B, Santiago ML, Gao F, Shaw GM, and B Hahn (2001). Functional analysis of the Simian Immunodeficiency virus Vpx protein: Identification of packaging determinants and a novel nuclear targeting domain. Journal of Virology. 75: 362-374.
Singh SP, Lai D, Cartas M, Mahalingam S, Kalyanaraman V, Murali R Srinivasan A. (2000). Structure functional studies of HIV-1 Vpr: Role of the putative loop region (residues 35-52) on cellular localization and virion incorporation in to virus particles. Journal of Virology. 74: 10650-10657.
Kim JJ, Trivedi N, Mahalingam S, Morrison. L, Tsai A, Chattergoon M, Dang K, Patel M, Ahn L, Chalian A, Boyer JD, Kieber-Emmons T, Agadjanyan MA, Weiner DB. (1998). Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine. Oncogene 17: 3125-3135.
Kim JJ, Trivedi N, Tsai A, Hu Y, Mahalingam S, Dang K, Morrison L, Ahn A, Doyle N, Wilson DM, Chattergoon M, Chalian A, Boyer JD, Agadjanyan MG, Weiner DB. (1998). Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. European Journal of Immunology. 28: 1089-1103.
Mahalingam S, Ayyavoo V, Patel M, Kiebber-Emmons T, Kao GD, Muschel RJ, Weiner DB. (1998). HIV-1 Vpr interacts with a human 34-mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. Proc. Natl. Acad. Sci. USA 95: 3419-3424.
Ayyavoo V, Rafaeli Y, Mahalingam S, Nagashunmugam T, Phung MT, Hamam A, Williams WV, Weiner DB. (1997). HIV-1 Viral protein R (Vpr) as a regulator of the target cell. PsyconeuroEndocrinology. 22: S41-S49.
Ayyavoo V, Mahboubi A, Mahalingam S, Ramalingam R, Williams WV, Sagar K, Green D, Weiner DB. (1997). HIV-1 Vpr suppresses immune activation and apoptosis through regulation of NF-kB. Nature Medicine 3: 1117-1123.
Ayyavoo V, Mahalingam S, Rafaeli Y, Kudchodkar S, Chang D, Nagashunmugam T, Williams VW, Weiner DB. (1997). HIV-1 viral protein R (Vpr) regulates macrophage and T-cell growth in vitro. Journal of Leucocyte Biology. 62: 93-99.
Ayyavoo V, Nagashunmugam T, Boyer J, Mahalingam S, Fernandes LS, Lee P, Lin J, Nguyen C, Chattargoon M, Goedert JJ, Friedman H, Weiner DB. (1997). Development of Cenetic Vaccines for Pathogenic Genes: Construction of attenuated Vif DNA immunization cassettes. AIDS 11: 1433-1444.
Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Weiner DB. (1997). Nuclear import, Virion incorporation and Cell cycle arrest/differentiation are mediated by distinct functional domains of HIV-1 Vpr. Journal of Virology. 71: 6339-6347.
Kim JJ, Bagarazzi ML, Trivedi N, Hu Y, Kazahaya K, Wilson DM, Chattergoon MA, Dang K, Mahalingam S, Chalian. AA, Agadjanyan MG, Boyer JD, Wang B, Weiner DB. (1997). Engineering of in vivo immune reponses to DNA immunization via codelivery of costimulatory molecule genes. Nature Biotechnology. 15: 641-646.
Mahalingam S, MacDonald BR, Ayyavoo V, Ugen KE, Agadjanyan MG, William WV, Weiner DB. (1997). Tumor Suppressive Effects of HIV-1 Vpr: In Vivo and In Vitro. DNA and Cell Biol. 16: 137-143.
Mahalingam S, Patel M, Collman RG, Srinivasan A. (1995). The carboxy-terminal domain is essential for stability not for virion incorporation of HIV-1 Vpr into virus particles. Virology 214: 647-652.
Mahalingam S, Collman RG, Patel M, Monken CE, Srinivasan A. (1995). Functional analysis of HIV-1 Vpr: Identification of determinants essential for subcellular localization. Virology 212: 331-339.
Mahalingam S, Collman RG, Patel M, Monken CE, Srinivasan A. (1995). Role of the conserved dipeptide Gly75 and Cys76 on HIV-1 Vpr function. Virology 210: 495-500.
Mahalingam S, Khan SA, Murali R, Jabbar MA, Monken CE, Collman RG, Srinivasan A. (1995). Mutagenesis of the putative a-helical domain of the Vpr protein of HIV- 1: Effect on stability and virion incorporation. Proc. Natl. Acad. Sci. USA 92: 3794-3798.
Mahalingam S, Khan SA, Jabbar MA, Monken CE, Collman RG, Srinivasan A. (1995). Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation. Virology 207: 297-302.
Mahalingam S, Khan SA, Jabbar MA, Monken CE, Collman RG, Srinivasan A. (1994). Genetic dissection of HIV-1 Vpr reveals distinct functional domains. AIDS Research and Human Retroviruses 10: 128.
Victor B, Mahalingam S, Sarojini R. 1985. Cytopathological effects of cadmium on the freshwater prawn Macrobrachium idae. Indian J. Fish. 32: 478-480.
Victor B, Mahalingam S, Sarojini R. 1986. Toxicity of mercury and cadmium on oocyte differentiation and vitellogenesis of the teleost, Lepidocephalichtyhs termalis ( Bleeker). J. Environ. Biol. 7: 209-214.
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| Contact Information |
| Email: |
maha<at>cdfd.org.in |
| Phone: |
+91-40-27151344-46-47-48 Extn.1203
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+91-40-27151344 |
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| Last updated on: 13 September, 2006. |
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