Squamous cell carcinoma of the tongue (SCCT) is a unique subtype of head and neck cancer because of its relatively higher incidence in the younger age group as well as in nonsmokers. It is also significantly more aggressive than other Head and Neck cancers due to a propensity for rapid metastatic spread. We have performed a comprehensive genomic and clinico-pathological analysis of SCCT that has unraveled a unique cross talk between P53 mutation and status of codon 72 polymorphism. We are currently pursuing genome-wide chromatin immunoprecipitation and RNA seq analysis to identify and characterize possible differential transcriptional targets of mutant and wild type P53.