Home | Site Map | Contact Us | Hindi Version
About Us Services Research Publications Group Leaders RTI Act Awards & Honours Careers Web Mail
 
Dr. Murali Bashyam
Research Interests
Molecular Oncology Group
Publications
Past Members
Awards, Fellowships and Honours
 
Home » Molecular Oncology » Research
Molecular Oncology
Molecular Characterization of early-onset rectal cancer

Colorectal cancer (CRC) is the third most common cancer worldwide and is perhaps the best understood of all cancers. Although rapid advances have been made in patient management and therapy for most forms of CRC, our understanding of sporadic early-onset rectal cancer (EORC), the predominant CRC subtype in India, is limited. We have performed the first comprehensive molecular and clinico-pathological characterization of CRC from India. Surprisingly, a significantly high proportion of EORC do not appear to be driven by either of the two canonical tumorigenesis pathways namely Wnt activation and mismatch repair inactivation that drive a majority of CRC worldwide. In addition, EORC also exhibits unique features with respect to chromosomal instability and KRAS mutation status. Efforts are currently underway, using next generation RNA and exome sequencing, to understand the biology of this unique CRC subtype. In parallel, our comprehensive studies on the familial cancer syndrome Hereditary Non-Polyposis Colorectal Cancer has revealed involvement of novel genetic lesions among Indian patients.

Fig.1. Identification of differential copy number alterations in Wnt- microsatellite stable early-onset rectal cancer (RC). aCGH carried out on genomic DNA isolated from early-onset RC samples reveal a recurrent amplification at 17q12 harboring ERBB2 and GRB7 oncogenes.
People involved
  • Raju Kumar : SRF
  • Pratyusha Bala : JRF
  • Ashmala Naz : JRF
  • K Viswakalyan : Research Assistant
  • V Chandrashekhar : Junior Project Technician
Funding Agencies : NIH; DBT; DST
Contact Information
Email: bashyam<at>cdfd.org.in

Phone: +91-40-24749383
Fax: +91-40-24749448
Last updated on : Tuesday, 14th July, 2015.

Copyright @ 2008 CDFD.