Last decade of biomedical research, there has been a remarkable convergence of interest in the powerhouse of cells, the mitochondria. Mitochondrial dysfunction is associated with a broad spectrum of human disorders, ranging from rare, inborn errors of metabolisms to common, age-related conditions, including cardiovascular and neurodegenerative diseases. However, the emerging field of mitochondrial medicine is hindered by the complexity of these organelles and breadth of implication in disorders, leading to a lack of mechanistic insights, biomarker discovery, and therapeutic targets.
The long-term goals of our group are to explore the new genes that are associated with mitochondrial disorders, understand the molecular mechanisms, and develop theragnostics (diagnosis and treatment).
Investigating the interaction between mtDNA and nDNA using next-generation sequencing.
Multi-omics approach to understand mitochondrial disorders
Delineate the molecular mechanism leading to neuronal loss and neurological defects in mitochondrial disorders.
In addition, we are also interested in identifying the novel genetic cause and functional characterization using cellular models of other rare genetic disorders.