CDFD :: Computational & Functional Genomics

Mapping the molecular pathways in Plasmodium falciparum.
Comparative Genome analysis of Plasmodium falciparum and other model organism,
Experimental approaches such as GST pulldown, Two hybrid, Phage display etc to find Protein-Protein Interactions and GFP fusion approach to study intracellular traficking pathway of Plasmodium proteins to the organells using Confocal microscopy

Plasmodium Genome Annotation Based on Protein Fold Recognition and Experimental Validation.
Protein folds are considered more conserved that protein sequences. Therefore we are interested in knowing: Can we identify and annotate Plasmodium falciparum genomes using fold recognition? How do we experimentaly validate such predictions using experimental techniques like UV/Fluroscence/CD/Mass spectroscopy?

Ongoing Ph.D. projects
Funding: CSIR NMITLI

Development of algorithms and tools for functional genomics
Sailu Yellaboina, Jayashree Sheshadri, B. Rami Reddy, Sarita Ranjan, Akash Ranjan
Funding: CSIR NMITLI

Gene regulatory network in Corynebacterium diphtehriae
Sarita Ranjan, Akash Ranjan
Funding: CSIR NMITLI (partial)

Characterization of DNA-protein interaction and gene regulation in Mycobacterium tuberculosis
Vaibhav Vindal, Sailu Yellaboina, Sarita Ranjan, Akash Ranjan
Funding: CSIR NMITLI (partial)

Characterization of protein-protein interaction in Plasmodium falciparum and Mycobacterium tuberculosis
Sarita Ranjan, P. Uma Devi, Akash Ranjan
Funding: DST, DBT, DRDO

Functional genomics of Plasmodium falciparum: Amino Acid substitution and Definition of molecular pathways
P. Uma Devi, Sarita Ranjan, Jayashree Sheshadri, Akash Ranjan
Funding: CSIR NMITLI

Genomics approach to the identification of possible drug targets for Mycobacterium tuberculosis
Akash Ranjan
Funding: CSIR NMITLI