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Molecular Genetics
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Current Research Interests
Development and
application of molecular markers, genetic characterization, molecular
mapping, introduction of baculovirus resistance through transgenic
approach, identification and characterization of Z and W chromosome
linked genes in silkworm and molecular analysis of antibacterial and
antiviral immunity.
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Towards
this direction our group has developed and characterized
microsatellites and FISSR markers in silkworm. “SilkSatDb” a
comprehensive database of microsatellites has been constructed.
Microsatellite linkage map has been generated based on biphasic
backcross strategy. The utility of these microsatellites for
population analysis has been demonstrated. Conservation of the
microsatellite loci across different silkmoths has been studied.
Microsatellites as a tool to understand evolutionary dynamics is
another area of interest. Mutations in the motifs and flaking
sequences as well as distribution of microsatellites in the genome
are being pursued. Silkworm Z-linkage map has been constructed based
on microsatellite markers, ISSR markers and sequence characterized
RAPD markers. Analysis of Z-linked genes and syntenic relationship
with other insects in terms of presence and functionality of Z-linked
genes and dosage compensation are future interests. Deciphering
sex-determination pathway in silkworm stimulates fundamental research
interests in addition to having profound commercial connotations. We
have initiated a study of sex-specific and sex-chromosome-specific
expression of genes. Baculoviral infection causes 50% of all the
infection in the silkworms, Bombyx mori. Developing transgenic
silkworm for viral resistance through RNAi approach is being developed.
Application of molecular markers for studying phylogenetics of
basmati rice cultivars, analysis of varietal purity and quantitative
detection of adulterants in the traditional basmati grain samples-
represent additional research interests of our group.
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Dr. J.Nagaraju
Molecular Genetics Group
Databases
T-O-T
IGG
Publications
Links
CONTACT INFORMATION
Email :
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silkmoth@cdfd.org.in
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Phone :
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+91-40-27151344-46-47-48 extn.1100, 27171427
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Fax :
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+91-40-27155610
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Last updated on : 7th June, 2006. |