Project : Prediction of Deleterious SNPs in Protein Superfamilies of interest

Human membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response ,serving as drug targets and setting drug levels. Moreover,variations in this membrane transporters may contribute to interindividual differences in the response to drugs.This variation is mostly due to non-synonymous single nucleotide polymorphisms (nsSNPs) that alter the encoded amino acid sequences and are thus likely to affect the function of the proteins and thus represent disease modifiers. There are estimated 100,000 to 300,000 nsSNPs in the human genome and the ability to predict the functionally significant variants is still limited. Availability of various human membrane transporter databases allowed us to perform in silico analysis of this transporter proteins especially ATP Binding Cassette(ABC) superfamily. People involved

Vishal Acharya Junior Research Fellow

Posters Presented

Vishal Acharya and Nagarajaram, H.A.(2007): "In silico analysis of candidate nsSNPs from public NCBI SNP database in Human Membrane Transport Proteins." presented at INDO-AUSTRALIAN CONFERENCE ON HUMAN VARIATIONS AND PHARMACOGENOMICS, 2007 Manipal.